Natural Immune System Literature

Books

Papers and articles

Selected and classified in a "reading course list" (the list is not stabilized and finished)

Immune System Modeling and Simulation

Books

  1. L. M. Sompayrac. "How the Immune System Works", 2nd Edition. Blackwell Publishing, 2003.

  2. R. A. Goldsby, T. J. Kindt, J. Kuby, B. A. Osborne . "Immunology", 5th edition. W H Freeman & Co., January 2003. Comment: Support-material on the web (Self-learning and self-testing tools; immune system vocabulary and definitions): 5th edition: http://bcs.whfreeman.com/immunology5e/  (4th edition: http://www.whfreeman.com/kuby/ )

Papers and articles

  1. R. Medzhitov and C. A. Janeway. "Innate immunity",  in The New England Journal of Medicine, Volume 343:338-344, August 3, 2000. (pdf) (Comments: " ... In this article we will outline the ways in which the innate immune system interacts with and controls adaptive immune responses." ; the article is written tree years ago...)

  2. T. W. Mak. "Order from Disorder Sprung: Recognition and Regulation in the Immune System". in Phil. Trans. R. Soc. Lond. A (2003) 361, 1235.1250, May 2003.     Comments: the paper is  explaining  the need for and the role of the acquired immunity; it is explaining the importance of correct signaling and regulation of the immune response. To listen to a related webcast talk click  here and select next title:  Public Lecture: "Order from Disorder Sprung: Recognition and Regulation in the Immune System".

  3. P. Matzinger. "Tolerance, Danger and the Extended Family". Annual Review of Immunology, 12:991-1045, 1994.

  4. P. Matzinger. "The Danger Model in it's Historical Context". Scandinavian Journal of Immunology, 54:4-9, 2001.

  5. P. Matzinger. "The Real Function Of The Immune System". (html)

  6. D.J. Smith, S. Forrest and A.S. Perelson, "Immunological memory is associative", In: International Conference on Multiagent Systems, Workshop notes: Workshop 4: Immunity Based Systems, p.62-70, Kyoto, Japan (1996).

  7. A. Mondino, A. Khoruts, and M. K. Jenkins. "The anatomy of T-cell activation and tolerance". Proc. Natl. Acad. Sci. USA, Vol. 93, pp. 2245–2252, March 1996. (pdf)

  8. Arakelyan L et al., Multi-Scale Analysis of Angiogenic Dynamics and Therapy, Ch. 7, in: "Cancer Modelling and Simulation", Luigi Preziosi ed., CRC Press, LLC, (UK), 2003. (pdf)

Selected and classified in a "reading course list" (the list is not stabilized and finished)

I. Overview

  1. L. M. Sompayrac. "How the Immune System Works", 2nd Edition. Blackwell Publishing, 2003. Chapter 1 or the whole book.

II. The Innate Immune System

  1. L. M. Sompayrac. "How the Immune System Works", 2nd Edition. Blackwell Publishing, 2003. Chapter 2.
  2. R. A. Goldsby, T. J. Kindt, B. A. Osborne. "Kuby Immunology", 4th edition. W H Freeman & Co., January 2000. Chapter 4.

III. B-cells

  1. L. M. Sompayrac. "How the Immune System Works", 2nd Edition. Blackwell Publishing, 2003. Chapter 3.
  2. R. A. Goldsby, T. J. Kindt, B. A. Osborne. "Kuby Immunology", 4th edition. W H Freeman & Co., January 2000. Chapter 5.

IV. T-cells and Antigen Presentation

  1. L. M. Sompayrac. "How the Immune System Works", 2nd Edition. Blackwell Publishing, 2003. Chapters 4 and 5.
  2. R. A. Goldsby, T. J. Kindt, B. A. Osborne. "Kuby Immunology", 4th edition. W H Freeman & Co., January 2000. Chapters 7 and 9.

  3. A. Mondino, A. Khoruts, and M. K. Jenkins. "The anatomy of T-cell activation and tolerance". Proc. Natl. Acad. Sci. USA, Vol. 93, pp. 2245–2252, March 1996. (pdf)

V. Lymphoid Organs

  1. L. M. Sompayrac. "How the Immune System Works", 2nd Edition. Blackwell Publishing, 2003. Chapter 6.

VI. Tolerance Induction

  1. L. M. Sompayrac. "How the Immune System Works", 2nd Edition. Blackwell Publishing, 2003. Chapter 7.

VII. Diseases of the Immune System

  1. L. M. Sompayrac. "How the Immune System Works", 2nd Edition. Blackwell Publishing, 2003. Chapters 8 and 9.
  2. P. Matzinger. "The Real Function Of The Immune System". (html)

VIII. AIDS and the Immune System

IX. Cancer and the Immune System

  1. L. M. Sompayrac. "How the Immune System Works", 2nd Edition. Blackwell Publishing, 2003. Chapter 9.
  2. Arakelyan L et al., Multi-Scale Analysis of Angiogenic Dynamics and Therapy, Ch. 7, in: "Cancer Modelling and Simulation", Luigi Preziosi ed., CRC Press, LLC, (UK), 2003. (pdf)

Immune System Modeling and Simulation

Till Bohbot: "Immune System Simulation" (a semester project done in our EPFL/LCA laboratory: report, presentation, animation and code)

Filippo Castiglione: CImmSim simulator (a cellular automata based simulator; source code)

Castiglione F, Selitser V, Agur Z. The effect of drug schedule on hypersensitive reactions: a study with a cellular automata model of the immune system. Ch. 12, in: "Cancer Modelling and Simulation", Luigi Preziosi ed., CRC Press, LLC, (UK), 2003.  (pdf)

Catherine Beauchemin. "Modeling the Immune System", a reading course final report. (pdf)

Catherine Beauchemin. "Modeling the diversity of the Immune System", a reading course final report. (pdf)

Catherine Beauchemin. "Cellular automata: Statistical Models with Various Applications", a short introduction to cellular automata. (ps)

Steven H. Kleinstein and Philip E. Seiden. "Simulating the Immune System", Computing in Science and Engineering, pp 69-77. July/August 2000. (pdf) (Comment: description of IMMSIM, a cellular automata model.)

Arakelyan L et al., Multi-Scale Analysis of Angiogenic Dynamics and Therapy, Ch. 7, in: "Cancer Modelling and Simulation", Luigi Preziosi ed., CRC Press, LLC, (UK), 2003. (pdf)